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Guido Guidotti
Structure and function of membrane proteins

The function and regulation of membrane proteins involved in the transfer of solutes (channels and transporters) and of information (receptors) across the plasma membrane are the subjects of research in this laboratory. The particular proteins under study are the insulin receptor, the (Na,K) ATPase, and insulin-activated cation channel, channels and transporters for ATP, and an ecto-apyrase.

For additional information:
http://www.mcb.harvard.edu/Faculty/Guidotti.html

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Publications:
Grinthal, A. and Guidoti, G. 2004. Dynamic motions of CD39 transmembrane domains regulate and are regulated by the enzymatic active site. Biochemistry 43: 13849-13858.

Wu, J.J. and Guidotti, G. 2004. Proreceptor dimerization is required for insulin receptor post-translational processing. J. Biol. Chem. 279: 25765-25773.

Zhong, X., Malhotra, R. and Guidotti, G. 2003. ATP transport into the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase. J. Biol. Chem. 278: 33436-33444.

Grinthal, A. and Guidotti, G. 2002. Transmembrane domains confer different substrate specificities and adenosine diphosphate hydrolysis mechanisms on CD39, CD39L1, and chimeras. Biochemistry 41: 1947-1956.

Booth, J. and Guidotti, G. 1997. Phosphate transport in yeast vacuoles. J. Biol. Chem. 272: 20408-20413.